Saturday, January 19, 2008

Crohn's Disease

It can be treated. They know what causes it. Why do most scientist and Doctors ignore this?

Here are some of the links, some of the evidence. I am no Medical Authority, just a scientist and a writer.

Scientists find how bacteria in cows milk may cause Crohn's disease

December 11, 2007 - Scientists at the University of Liverpool have found how a bacterium, known to cause illness in cattle, may cause Crohn's disease in humans.

The team found that a bacterium called Mycobacterium paratuberculosis releases a molecule that prevents a type of white blood cell from killing E.coli bacteria found in the body. E.coli is known to be present within Crohn’s disease tissue in increased numbers.

It is thought that the Mycobacteria make their way into the body’s system via cows’ milk and other dairy products. In cattle it can cause an illness called Johne's disease - a wasting, diarrhoeal condition. Until now, however, it has been unclear how this bacterium could trigger intestinal inflammation in humans.

Professor Jon Rhodes, from the University’s School of Clinical Sciences, explains: “Mycobacterium paratuberculosis has been found within Crohn’s disease tissue but there has been much controversy concerning its role in the disease. We have now shown that these Mycobacteria release a complex molecule containing a sugar, called mannose. This molecule prevents a type of white blood cells, called macrophages, from killing internalised E.Coli.”

Scientists have previously shown that people with Crohn’s disease have increased numbers of a ‘sticky’ type of E.coli and weakened ability to fight off intestinal bacteria. The suppressive effect of the Mycobacterial molecule on this type of white blood cell suggests it is a likely mechanism for weakening the body’s defence against the bacteria.

Professor Rhodes added: "We also found that this bacterium is a likely trigger for a circulating antibody protein (ASCA) that is found in about two thirds of patients with Crohn's disease, suggesting that these people may have been infected by the Mycobacterium."

Science Daily

All of which makes sense in regards to this website, which outlines a succesful treatment, based on treating for the Mycobacterium.

Somebody who has cured himself of Crohn's explains all.

Then you have other sites, more complex, but backing the same theory and treatment.
Treatment & diagnosis of Crohn's Disease
If you want to read a lot of evidence, read on.
From The Lancet

Is Crohn's disease caused by a mycobacterium?

The most plausible candidate is Mycobacterium avium subspecies paratuberculosis (MAP). Intriguingly, Koch's postulates may have been fulfilled for MAP and Crohn's disease, even though they still have not been met for Mycobacterium leprae and leprosy. In animals MAP causes Johne's disease, a chronic wasting intestinal diarrhoeal disease evocative of Crohn's disease. Johne's disease occurs in wild and domesticated animals, including dairy herds. Viable MAP is found in human and cow milk, and is not reliably killed by standard pasteurisation. MAP is ubiquitous in the environment including in potable water. Since cell-wall-deficient MAP usually cannot be identified by Ziehl-Neelsen staining, identification of MAP in human beings requires culture or detection of MAP DNA or RNA. If infectious in origin, Crohn's disease should be curable with appropriate antibiotics. Many studies that argue against a causative role for MAP in Crohn's disease have used antibiotics that are inactive against MAP. However, trials that include macrolide antibiotics indicate that a cure for Crohn's disease is possible.


Paratuberculosis And Crohn's Disease: Got Milk?

by Michael Greger, MD
Updated January 2001


Paratuberculosis Awareness & Research Association (PARA) is an organization of Crohn's disease patients, their families and others who are concerned about the relationship between MAP (Mycobacterium avium subspecies paratuberculosis) and Crohn's disease.


Over 20 years of independent research links a common disease in humans characterized by chronic diarrhea and severe abdominal pain with sick cows and contaminated milk.


Lots more links, but the bottom line is, it appears it is
caused by Mycobacterium avium subspecies paratuberculosis, it is hard to treat, (not everybody gets better from the antiobiotics), and it comes from cows.

More scientific stuff. All of which supports the latest findings.


Paratuberculosis or Johne's disease is a chronic enteritis of the cattle and other small ruminant animals caused by Mycobacterium avium subsp. paratuberculosis. In Argentina, the strains were characterized in beef and dairy cattle and deer in different genetic patterns by molecular tools. M. avium subsp. paratuberculosis has been linked in men to a chronic inflammation of the intestine, named Crohn's disease. There is clinical and experimental evidence to link M. avium subsp. paratuberculosis with Crohn's disease by PCR, positive bacteriological culture from mother milk, blood and affected tissues by in situ hybridization. The milk and sub-products might be one of the possible infection sources and it has been suggested that M. avium subsp. paratuberculosis could resist pasteurization. Several works showed that this mycobacteria could be present in retail milk of countries such as United Kingdom, USA, Czech Republic, and recently in Argentina. M. avium subsp. paratuberculosis was associated with different dairy products and water for human consumption. Therefore, it is possible that these food sources may have a role for transmission.


[Mycobacterium paratuberculosis in the intestine of patients with Crohn's disease] PubMed


Mycobacterium paratuberculosis DNA in Crohn's disease tissue. PubMed

I hope this makes sense.


tacocase said...

I have Crohn's. What causes it? A combo of defective genes and bacteria in cows' milk? I don't know. Debbie

JR said...

Oh snap. How did you find this Blog? It is a work in progress, a template to be filled in, and now I feel obligated, obligated to finish at least one entry. And so I will.

With evidence. Not my opinion, not my voice, but that of science, backed by hard work, evidence, data, the good stuff.

We stand on the shoulders of Giants...